Rational engineering of Fc/Fc receptor interactions to improve antibody potency
نویسندگان
چکیده
منابع مشابه
Antibody engineering for increased potency, breadth and half-life
PURPOSE OF REVIEW This review highlights recent developments in HIV-1 antibody engineering and discusses the effects of increased polyreactivity on serum half-lives of engineered antibodies. RECENT FINDINGS Recent studies have uncovered a wealth of information about the relationship between the sequences and efficacies of anti-HIV-1 antibodies through a combination of bioinformatics, structur...
متن کاملSurface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody
Highly effective HIV-1-neutralizing antibodies could have utility in the prevention or treatment of HIV-1 infection. To improve the potency of 10E8, an antibody capable of near pan-HIV-1 neutralization, we engineered 10E8-surface mutants and screened for improved neutralization. Variants with the largest functional enhancements involved the addition of hydrophobic or positively charged residues...
متن کاملIncreasing the potency and breadth of an HIV antibody by using structure-based rational design.
Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show exceptional potency and breadth. We determined structures of NIH45-46, a more potent clonal variant of VRC01, alone and bound to gp120. Comparisons with VRC01-gp120 revealed that a four-residue insertion in heavy chain complementarity-determining region 3 (CDRH3) contributed to increased interaction betwee...
متن کاملMicro-Components of Functional Quality in the Trade Centers Aiming to Improve Social Interactions
The internal architecture of the trade centers and the promoting their environmental quality, as an important factor affecting the behavior of customers, impose significant contribution to market as well as individuals’ desires to stay longer in the space. Considering the completeness of sustainable place model theory in the form of three criteria of functional, experimental-aesthetic, and env...
متن کاملMicro-components of Experimental-aesthetic Quality in Commercial Spaces Aiming to Improve Social Interactions
Environmental quality and different aspects of interior architecture of shopping centers as an effective factor on shopping behaviors of people is of a great importance in creating social interactions. Considering the comprehensiveness of sustainable place model in delivering environmental qualities (functional, experimental-aesthetic and environmental) as well as objectives of the research, th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2003
ISSN: 1465-542X
DOI: 10.1186/bcr718